The 2021-22 campaign delivered ultimate heartbreak for Genoa as The Griffins finished a crushing 19th in Serie A, ending their 15-season stay in the Italian top flight and confirming their relegation to Serie B. It was a turbulent year defined by a frantic revolving door of four different managers, including the brief, high-profile tenure of Andriy Shevchenko, and a crushing 26-match winless streak that sealed their fate. Amid the chaos, veteran forward Mattia Destro's 9 goals provided a rare, bright spark. The season remains a painful and defining chapter, marking the devastating end of an era for the league's oldest club.